Car T Cell Therapy Side Effects

The most common side effects seen are.

Car t cell therapy side effects. Car t cell therapy can cause a serious side effect known as cytokine release syndrome. Cytokine release syndrome crs. Neurologic events include encephalopathy. The 133 participants in the fred hutch clinical trial believed to be the largest sample size in any published study of car t cell therapy side effects had advanced leukemias or lymphomas that had proven resistant to standard therapies.

This happens when car t cells begin attacking cancer and trigger an. Low white blood. Some people have had serious side effects from this treatment especially as the car t cells multiply in the body to fight the cancer. While the therapy can lead to long lasting remissions for some patients with very advanced cancer it can also cause neurologic side effects such as speech problems tremors delirium and seizures.

Cytokine release syndrome which is similar to flu like symptoms headache. Car t cell therapy side effects. Despite the therapeutic successes of car t cell therapy the intervention carries the risk of severe side effects. This syndrome is caused when the transferred t cells or other immune cells responding to the new t cells release a large amount of cytokines into the blood.

Some side effects can be severe or fatal. Cytokine release syndrome crs you may have heard of the cytokine storm in 2018 when many people got seriously ill during flu season. When the modified t cells kill the tumor cells these then break into component parts and all the leftover gunk can be floating in your bloodstream. Serious side effects of this release can include very high fevers and dangerously low blood pressure in the days after treatment is given.

Car t cell therapy can trigger a range of side effects many of which begin subtly but can rapidly worsen. The possible side effects that your doctor will discuss with you include. As car t cells multiply they cause massive amounts of chemicals called cytokines to be released into the blood. A potentially serious complication is cytokine release syndrome crs also known as a cytokine storm.

Again tumor lysis is a side effect showing that the car t cell treatment is working perhaps too well. Cytokines are immune substances that have many different functions in the body.